Our program focuses on cutting-edge research at the intersection of computation and biology. Faculty in the Computational Biology program are engaged in cutting-edge research in a variety of areas, including computational genomics, systems biology, and bioinformatics. Explore opportunities with our world-class faculty across diverse research areas including genomics, AI in medicine, and more. Learn about our specialized training that prepares students for research excellence.
The best way to learn about the research being done by our faculty is to visit their websites and read their recent publications. You can find a list of faculty members and their websites on the faculty page. You can also browse papers from UVA COBI on PUBMED.
Recent Publications
1. Quantifying the impact of early life growth adversity on later life health.
View Goldman-Pham R, ..., Manichaikul A, Rich SS, ...Smith BM
Published: 2025 Nov 17
Commun Med (Lond)
2. Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.
View Deutsch AJ, Bell AS, Michalek DA, Burkholder AB, Nam S, Kreienkamp RJ, Sharp SA, Huerta-Chagoya A, Mandla R, Nanjala R, Luo Y, Oram RA, Florez JC, Onengut-Gumuscu S, Rich SS, Ng MCY, Motsinger-Reif AA, Manning AK, Mercader JM, Udler MS
Published: 2025 Nov 14
Diabetes
3. Characterizing Spatiotemporal Expansion of Pseudomonas aeruginosa Communities in Polymer and Mucin Gel Environments.
View Kim MS, Kolling GL, Ribbeck K, Peirce SM, Papin JA, Ford RM
Published: 2025 Nov 13
Biotechnol Bioeng
4. N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness.
View Robbins JM, ..., Rich SS, ...Gerszten RE
Published: 2025 Nov 12
Circulation
5. Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program.
View Wang N, ..., Rich SS, ...Yu B
Published: 2025 Nov 6
Am J Hum Genet
6. ConceptDrift: leveraging spatial, temporal and semantic evolution of biomedical concepts for hypothesis generation.
View Shariatmadari AH, Jafari A, Guo S, Srinivasan S, Sheffield NC, Zhang A, Jha K
Published: 2025 Nov 1
Bioinformatics
7. Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases.
View Wang M, Zheng Y, Lai M, Saake E, Liu X, Guo X, Taylor KD, Huan T, Joehanes R, Nannini DR, Zhang K, Lake NJ, Castellani CA, Rich SS, Rotter JI, Liu Y, Raffield LM, Carson AP, Fornage M, Ma J, Arking DE, Hou L, Levy D, Liu C
Published: 2025 Oct 24
Aging Cell
8. AI-powered programmable virtual humans toward human physiologically-based drug discovery.
View Wu Y, Bourne PE, Xie L
Published: 2025 Oct 8
Drug Discov Today
9. HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry.
View Michalek DA, Tern C, Robertson CC, Chen WM, Onengut-Gumuscu S, Rich SS
Published: 2025 Oct 2
Diabetologia
10. The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment-2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum.
View Evans-Molina C, Dor Y, Lernmark Å, Mathieu C, Millman JR, Mirmira RG, Pociot F, Redondo MJ, Rich SS, Richardson SJ, Rickels MR, Leslie RD
Published: 2025 Oct 1
Diabetes
11. The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment-2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum.
View Evans-Molina C, Dor Y, Lernmark Å, Mathieu C, Millman JR, Mirmira RG, Pociot F, Redondo MJ, Rich SS, Richardson SJ, Rickels MR, Leslie RD
Published: 2025 Oct 1
Diabetes Care
12. Associations of High Attenuation Area-Related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities.
View Kim JS, ..., Rich SS, ...Manichaikul A
Published: 2025 Oct
Am J Respir Crit Care Med
13. Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.
View Guo B, ..., Rich SS, Manichaikul A, ...Darst BF
Published: 2025 Oct 1
Nat Commun
14. Triple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer.
View Alencar GF, Mohamed AO, Burnett MG, Jean SS, Nelson AR, Su Y, Voillet V, Bates BM, Rodgers Suarez M, Ruskin SL, Trieu L, Lam JL, Bekiranov S, Gottardo R, Greenberg PD, Anderson KG
Published: 2025 Sep 30
Proc Natl Acad Sci U S A
15. Transcriptional Condensates: Epigenetic Reprogramming and Therapeutic Targets in Hematologic Malignancies.
View Qiu K, Yin Q, Zang C, Tao J
Published: 2025 Sep 27
Cancers (Basel)
16. Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D.
View Hu X, Webb-Robertson BM, Parikh HM, Nakayasu ES, Onengut-Gumuscu S, Chen WM, Frazer-Abel A, Metz TO, Rich SS, Rewers MJ, Manichaikul A
Published: 2025 Sep 26
Commun Biol
17. PATTY corrects open-chromatin bias for improved bulk and single-cell CUT&Tag profiling.
View Hu SS, Su Z, Liu L, Chen Q, Grieco MC, Tian M, Dutta A, Zang C
Published: 2025 Sep 26
Res Sq
18. Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate.
View Zhao X, Hu SS, Lee WH, Zakrzewski JL, Mi QS, Rosenstein RK, Zang C, Ma X, Xue HH
Published: 2025 Sep 12
Sci Immunol
19. PATTY corrects open chromatin bias for improved bulk and single-cell CUT&Tag profiling.
View Hu SS, Su Z, Liu L, Chen Q, Grieco MC, Tian M, Dutta A, Zang C
Published: 2025 Sep 7
bioRxiv
20. Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling.
View Wierbiłowicz K, Yang CS, Almaghasilah A, Wesołowski PA, Pracht P, Dworak NM, Masur J, Wijngaarden S, Filippov DV, Wales DJ, Kelley JB, Ratan A, Paschal BM
Published: 2025 Sep
EMBO J
21. The heterogeneity of type 1 diabetes: implications for pathogenesis, prevention, and treatment-2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum.
View Evans-Molina C, Dor Y, Lernmark Å, Mathieu C, Millman JR, Mirmira RG, Pociot F, Redondo MJ, Rich SS, Richardson SJ, Rickels MR, Leslie RD
Published: 2025 Sep
Diabetologia
22. Steroid hormone biosynthesis and dietary related metabolites associated with excessive daytime sleepiness.
View Faquih T, Potts KS, Nagarajan P, Yu B, Kaplan R, Isasi CR, Qi Q, Taylor KD, Liu PY, Strausz SJ, Ollila HM, Huang T, Tracy RP, Johnson C, Rich SS, Clish CB, Rotter JI, Redline S, Sofer T, Wang H
Published: 2025 Sep
EBioMedicine
23. Genome-wide association study provides novel insight into the genetic architecture of severe obesity.
View Krishnan M, ..., Rich SS, ...Graff M
Published: 2025 Sep
PLoS Genet
24. Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia.
View Li R, ..., Rich SS, ...Scott LJ
Published: 2025 Aug 30
HGG Adv
25. CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia.
View Prajapati SC, Meydan C, Neelamraju Y, Wang Z, Fan H, Dunham N, Dillon R, Gandara JA, Lee T, Sheridan C, Zumbo P, Becker MW, Bullinger L, Carroll MP, D'Andrea RJ, Levine RL, Mason C, Melnick AM, Zang C, Bekiranov S, Garrett-Bakelman FE
Published: 2025 Aug 27
bioRxiv
26. DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.
View Carbonneau M, ..., Rich SS, ...Ma J
Published: 2025 Aug 19
Circulation
27. The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection.
View Brown AC, Uddin MJ, Munday RM, Naz F, Moreau GB, Ramakrishnan G, Rich SS, Haque R, Wojcik GL, Duggal P, Marie C, Petri WA Jr
Published: 2025 Aug 13
mBio
28. HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry.
View Michalek DA, Tern C, Robertson CC, Chen WM, Onengut-Gumuscu S, Rich SS
Published: 2025 Aug 12
medRxiv
29. Data sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking.
View Smith JL, Wong Q, Hornsby W, Conomos MP, Heavner BD, Kullo IJ, Psaty BM, Rich SS, Stilp AM, Tayo B, Zhang Y, Natarajan P, Nelson SC, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Data Sharing Working Group, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium
Published: 2025 Aug 7
Am J Hum Genet
30. IsoBayes: a Bayesian approach for single-isoform proteomics inference.
View Bollon J, Shortreed MR, Jeffery E, Jordan BT, Miller R, Cavalli A, Smith LM, Dewey CN, Sheynkman GM, Tiberi S
Published: 2025 Aug 2
Bioinformatics
31. Coronary Artery Disease-Based Polygenic Risk Score in Early-Onset Acute Myocardial Infarction Subtypes.
View Dong W, Lu Y, Li SX, Sawano M, Caraballo C, Liu Y, Khera A, Philippakis A, Dreyer R, Lichtman J, D'Onofrio G, Spatz ES, Herrington D, Post WS, Rich SS, Rotter JI, Krumholz HM
Published: 2025 Aug
JACC Adv
32. Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox.
View Schertzer MD, Stirn A, Isaev K, Pereira L, Park SH, Das A, Réal A, Jeffery ED, Harbison C, Wessels HH, Sheynkman GM, Sanjana NE, Knowles DA
Published: 2025 Jul 29
Nat Commun
33. Genome-wide Gene by Sleepiness Interaction Analysis for Sleep Apnea.
View Nagarajan P, ..., Rich SS, ...Wang H
Published: 2025 Jul 28
Sleep
34. Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
View Huerta-Chagoya A, ..., Chen WM, Rich SS, ...D-PRISM Consortium
Published: 2025 Jul 23
medRxiv
35. Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies.
View Templeman EL, Ferrat LA, Parikh HM, You L, Triolo TM, Steck AK, Hagopian WA, Vehik K, Onengut-Gumuscu S, Gottlieb PA, Rich SS, Krischer JP, Redondo MJ, Oram RA, Type 1 diabetes TrialNet Study Group
Published: 2025 Jul 21
BMC Med
36. CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.
View Herasymenko O, ..., Bourne PE, ...Schapira M
Published: 2025 Jul 14
J Chem Inf Model
37. Genetic Risk and Transition through Preclinical Stages of Type 1 Diabetes.
View Steck AK, Parikh HM, Triolo TM, Ferrat L, You L, Gottlieb PA, Oram RA, Onengut-Gumuscu S, Krischer JP, Rich SS, Redondo MJ
Published: 2025 Jul 9
J Clin Endocrinol Metab
38. A data model for population descriptors in genomic research.
View Khan AT, Adebamowo C, Fullerton SM, Hirbo J, Konigsberg IR, Kraft P, Martin I, Nelson SC, Ramsay M, Wojcik GL, Adebamowo SN, Conomos MP, Darst BF, Hysong MR, Li Y, Martin AR, Mathias RA, Rich SS, Sakoda LC, Schrider DR, Sharma J, Smith JL, Sun Q, Zhang Y, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium, Gogarten SM
Published: 2025 Jul 3
Am J Hum Genet
39. Perplexity as a Metric for Isoform Diversity in the Human Transcriptome.
View Schertzer MD, Park SH, Su J, Sheynkman GM, Knowles DA
Published: 2025 Jul 2
bioRxiv
40. Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes.
View Jumentier B, Gamache I, Michalek DA, Chen WM, Onengut-Gumuscu S, Rich SS, Polychronakos C, Manousaki D
Published: 2025 Jul
EBioMedicine
41. Ten simple rules for developing a training program.
View Blevins LB, Harrigan AM, Janes KA, Papin JA
Published: 2025 Jul
PLoS Comput Biol
42. Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score.
View Deutsch AJ, Bell AS, Michalek DA, Burkholder AB, Nam S, Kreienkamp RJ, Sharp SA, Huerta-Chagoya A, Mandla R, Nanjala R, Luo Y, Oram RA, Florez JC, Onengut-Gumuscu S, Rich SS, Motsinger-Reif AA, Manning AK, Mercader JM, Udler MS
Published: 2025 Jun 22
medRxiv
43. Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity.
View Akhshi T, Hu SS, Wheeler E, Hellriegel C, Richardson DS, Cayting N, Mvula W, Ahmed B, Jeselsohn R, Zang C, Brown M
Published: 2025 Jun 21
bioRxiv
44. Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells.
View Bartosik AR, Hou PC, Tang S, Vaughn JP, Smaldino PJ, Ratan A, Mayo MW, Wang YH
Published: 2025 Jun 20
Nucleic Acids Res
45. Reframing the role of the objective function in its proper context for metabolic network modeling.
View Islam MM, Shao W, Batavia M, Ford RM, Palsson BO, Nielsen J, Maranas CD, Lee SY, Papin JA
Published: 2025 Jun 18
Cell Syst
46. Quantifying the impact of early-life growth adversity on later-life health.
View Goldman-Pham R, ..., Manichaikul A, Rich SS, ...Smith BM
Published: 2025 Jun 17
medRxiv
47. Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.
View Shade LM, ..., Rich SS, ...Sarnowski C
Published: 2025 Jun 13
medRxiv
48. TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin.
View Liang J, Wang Y, Demmerle J, He BJ, Ricketts CJ, Marston Linehan W, Zang C, Cai D
Published: 2025 May 3
bioRxiv